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Scientists searched for cancer-related mutations by comparing the DNA in these cells and the patient's healthy skin cells.
Cancer studies focus on the identification of somatic mutations by comparing sequencing results of tumor/normal pairs from one subject.
First, we evaluated the effects of individual mutations by comparing COL4A1 or COL4A2 levels in MEFs isolated from Col4a1 +/+ and Col4a1 +/mut littermates within each strain.
In order to test accuracy of our methods, we emulated the existence of somatic point mutations by comparing two unrelated human genomes.
Next, we determined whether SNPs positioned in consensus coding sequences introduce synonymous or nonsynonymous mutations by comparing the translated amino acids from the reference and variant sequences.
We have implemented Veridical, a software program that automates confirmation of mRNA splicing mutations by comparing sequence read-mapped expression data from samples containing variants that are predicted to cause defective splicing with control samples lacking these mutations.
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Using voxel-based morphometry (VBM) we quantitatively assessed the extent of structural changes brought on by the genetic mutation by comparing mean cortical curvature, cortical thickness, and gray matter volume in 34 cortical areas between patient and an age-, sex-, and education-matched control group.
Stedman and colleagues dated the origins of the mutation by comparing difference between the human gene and that of other primates.
The principal analysis focused on the FAAH 385 C→A (P129T) mutation by comparing plasma ECS metabolite levels in the FAAH 385 minor A allele carriers versus wild-type C/C carriers in both groups.
Earlier studies explored genome-wide mutation patterns by comparing the genomic sequences of closely related strains.
The gene signature and associated predictive model were built independently of the p53 mutation status, by comparing the chemical sensitivities of both p53 wild-type and mutant cell lines.
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times by comparing
transfer by comparing
mutant by comparing
mutations by applying
mutations by destabilising
mutations by decreasing
mutations by ionizing
mutations by crossing
mutations by designing
mutations by reversing
mutations by increasing
mutations by performing
mutations by swapping
mutations by denaturing
mutations by inserting
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