Sentence examples for mutations by causing from inspiring English sources

Processes that increase the rate of changes in DNA are called mutagenic: mutagenic chemicals promote errors in DNA replication, often by interfering with the structure of base-pairing, while UV radiation induces mutations by causing damage to the DNA structure.

Aflatoxin may increase the proportion of p53 mutations by causing a single mutation, the codon 249 G > T transversion, thus explaining some of the excess liver cancer associated with aflatoxin exposure.

68 The proposed mechanism common to all three studies is that treatment with a BRAF inhibitor accelerates cutaneous tumor development in skin cells harboring pre-existing (H RAS mutations, by causing hyperproliferation through mitogen-activated protein kinase pathway signaling as in the models of vemurafenib resistance.

This mutation, by causing a premature stop codon, is of obvious pathogenic consequence and has already been reported in the spectrum of mutations occurring in malignant rhabdoid tumors [ 18].

It could also decrease mtDNA quality by causing mutations or deletions.

Carcinogenic agents induce cancer by causing genetic mutations that allow cells to escape normal biological controls.

The REP mutations, by contrast, cause local structural perturbations that affect the whole of the ZRS acting in the manner of an enhanceosome (Panne, 2008).

The eight HBG strains tested above were outcrossed with N2 to remove ben-1 and vps-45 mutations, and side mutations caused by UV/TMP treatment.

This chapter provides molecular insights into acetylcholine receptor structure and function revealed by mutations causing congenital myasthenic syndromes (CMS).

AR HIES has been shown to be caused by mutations causing loss of tyrosine kinase 2 (TYK2) (OMIM 611521) or dedicator Of cytokinesis 8 (DOMIM) (OMIM 243700).

Key to this research will be elucidating the signalling pathways that are disrupted by mutations causing neurodegenerative disease.