Sentence examples for mutations by a from inspiring English sources

Hoping to patch up the protein, researchers at Johns Hopkins University in Baltimore, Maryland, and Memorial Sloan-Kettering Cancer Center in New York City, took mutated p53 genes and introduced additional random mutations by a process called PCR mutagenesis.

In addition, 5 replicates of SPT15 mutations by a total number of 250 were selected, and their stability tests were examined.

To understand how the side chain interactions at the dimer interface stabilize the subunit association, we studied the structural and functional consequences of introducing interfacial mutations by a combination of molecular dynamics (MD) simulation and biochemical characterization.

We also quantified the individual contributions of the resistance to denaturation ([urea]1/2) and cooperativity of unfolding (m) to the variations of stability and the energy of coupling between mutations by a novel approach.

If the EGFR deletions were hotspots of mutations by a novel mechanism, they may be predisposed to occur early in embryogenesis.

The primary tumors of these patients had been analysed for the presence of KRAS mutations by a central laboratory prior to cetuximab administration.

The identification of a range of rare genetic mutations by an international collaboration known as the Autism Genome Project, involving scientists in the US, Canada and Europe, will further undermine the arguments of those who have claimed that the MMR vaccine, against measles, mumps and rubella, is somehow to blame.

Our study also provides the first evidence of a pathogen that can at least partly counter the induction of mutations by an infected plant, a further indication of Agrobacterium's sophisticated infective capabilities.

Finally, we decompose the fitness contributions of pre-existing and de novo mutations by creating a large recombinant library of adaptive mutations in an ensemble of genetic backgrounds.

This analysis gives additional support to the interpretation of correlated mutations as "one mutation followed by a compensatory mutation".

Long uninterrupted CAG repeats are known to be a substrate for expansion mutation by a variety of mechanisms.