Sentence examples for mutations beyond the from inspiring English sources

KRAS mutations beyond the "hotspots" can be oncogenic by conveying selective growth advantage to the cells.

We still discuss the Koel mutations as potential large effect mutations beyond the scope of our model.

However, currently existing haplogrouping tools only make use of haplogroup-defining mutations, whereas private mutations (beyond the haplogroup level) can be additionally informative allowing for enhanced haplogroup assignment.

This would indicate that bulky DNA adducts did not form, as under these conditions, different mutations, beyond the spontaneous types, should have been detected.

Moreover, we have demonstrated that the introduction of adaptive mutations beyond the introduced xylose utilization genes is able to improve S. cerevisiae xylose metabolism.

Nonetheless, the localization of the adaptive mutations beyond the introduced xylose utilization genes demonstrates the complexity of the system that involves many additional genes, providing substantial room for significant biotechnological improvements in xylose utilization efficiencies.

In contrast, genes involved in cell adhesion pathways were only amplified in cluster P2, indicating that the clones in cluster P2 might be under an opposite pressure to clusters P1 and M. Whether metastasis requires mutations beyond those required to drive the primary tumor is controversial [ 25].

This strategy cannot identify mutations beyond those targeted [ 10].

If we identify those groups where seeding metastasis may require driver mutations beyond those required for primary tumorigenesis, debulking surgery might not be useful.

In pancreatic cancer, seeding metastasis may require driver mutations beyond those required for primary tumors, and phylogenetic trees across metastases show organ-specific branches [ 27].

In contrast to the low-grade foci, 67 of 808484%) high-confidence somatic mutations identified in high-grade foci were shared with metastatic disease and metastatic foci had few mutations beyond those identified in high-grade disease (Fig. 3a,c).