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Exact(5)
Hence, the number of mutations between two species could be used to tell when species diverged, even without fossil evidence.
Since replication and transcription processes have been widely considered to bias the occurrence of mutations between two complementary DNA strands [9], [17], the inversion of large number of protein-coding genes should have counteracted some of the affect of reversed replication origin on strand asymmetry.
The total number of somatic mutations between two groups was compared using a Student's t test.
This method also estimates the DFEs of new deleterious mutations from the polymorphisms data and then uses the inferred DFE to predict the numbers of substitutions originating from neutral and slightly deleterious mutations between two species.
Mutations between two amino acids that are not convertible by a single-base change (e.g., phenylalanine {TTT, TTC} to asparagine {AAT, AAC}) can result either through multiple-base changes or through a transient intermediate amino acid (such as tyrosine {TAT, TAC}).
Similar(55)
For example, Lynch and Katju [ 24] calculated that if each of two paralogs had accrued ten mutations since the duplication event, an absolute difference of at least nine mutations between the two copies would be required to reject the null hypothesis of equal rates.
Analysis confirmed that these two genes shared a high degree of similarity having no more than eight mutations between the two different sopE1 alleles.
Sequence alignments indicate that there are five mutations between these two proteins, and these may contribute to the increased lytic activity of PlyAB1.
We compute the probability distribution of the number of mutations shared between two randomly chosen taxa in a Yule tree under discrete Markov mutation models.
Each method utilizes a likelihood component that describes the probability that a set of mutations occurs between two pathogen samples from different hosts, given their epidemiological relationship.
Interestingly, despite the huge difference in the expression profiles, these two actin genes only differ by four amino acids, indicating that small mutations between these two genes may have large functional consequences.
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