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The final presentation was by R Katherine Alpaugh Fox Chase Cancerr Center) and described differences in genetic mutations between different tissue sources from the same patient.
SSCP is a very sensitive technique for the detection of single point mutations between different DNA fragments (Grieu et al. [2004]; Muangprom et al. [2005]).
A, Comparison of proportions of non-singleton mutations between different genomic regions.
Comparisons of observed mutations between different groups of patients were performed using Fischer exact test.
The proportion of mutations causally implicated in cancer is still unknown especially due to the high number of mutations between different tumors [ 5- 8].
Indeed, previous genome sequencing studies have reported few common mutations between different tumour foci within the same prostate (Lindberg et al. 2013), highlighting marked intra-tumour heterogeneity and the absence of a genetic founder mutation.
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Alternatively, the observed variability of stop codon frequencies relative to the average expectation (compare Figure 1A and 1B) may be due to slight changes in selection pressure on TAG and the rates of A < − > G mutation between different species.
However, like the wildtype IgG subclass binding hierarchies, the effect of the mutations varied between different receptors.
The cluster-graph method could not be applied to the combined spoligotyping-VNTR data, as the manual inference of tree edges between genotypes needs to be supported by the number of mutations events between different genotypes.
We confirmed previous findings of pronounced differences in mutation frequency between different histopathological subtypes.
There was no significant difference in mutation rate between different molecular laboratories (F = 1.46, d.f. = 35,41, P = 0.12).
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