Sentence examples for mutations before the from inspiring English sources

Mutations within the cysteine-rich FZD and truncating mutations before the kinase domain result in the inhibition of axonal outgrowth, suggesting a ligand-mediated function, but kinase activity may be dispensable.

In addition, phase 2 mutations can be expressed independently of phase 1 mutations, before the passage of the replication fork.

This procedure was iterated so that the oligonucleotide experienced 2*106 mutations before the search was terminated.

Plasma acylcarnitine profiles were performed in 17 of 18 patients with SLC52A2 mutations before the initiation of high-dose oral riboflavin therapy.

This finding indicates that GK acquired its new protein-binding function through a relatively simple, high-probability genetic path, rather than a long trajectory that required many specific mutations before the new function could be established.

It has been suggested that impairment in collagen turnover could be a component of the disease phenotype and that it appears as an early manifestation of sarcomere gene mutations, before the development of overt LV hypertrophy.

The results for the four cases below are presented in terms of two key model outputs: (1) relative tumorigenic efficiency of mutator vs. non-mutator pathways, Nrel, and (2) the minimum fold increase in mutation rate required from a mutator mutation before the mutator pathway has a relative tumorigenic efficiency greater than or equal to 1, termed α50%.

The 985A>G mutation was the prevalent MCAD mutation before the NBS era and patients were identified because of hypoglycaemia or hepatopathy [16].

The Swedish mutation is actually a double mutation before the A β domain (K670 M and N671 K) resulting in increased total A β production and changes inintercellular A β localization [ 45].

The cumulative 5-, 10-, and 15-year risks of CBC were calculated using Kaplan Meier analysis including only patients who underwent DNA testing for BRCA1/2 mutation before the diagnosis of CBC, to correct for potential selection bias.

Only those patients who underwent DNA testing for BRCA1/2 mutation before the diagnosis of contralateral breast cancer were included Left truncation was applied to correct for survival bias that may occur in studies with patient recruitment at a variable time after diagnosis (see statistical analysis).