The arc2 mutation bears a single nucleotide substitution, which converts Ala-342 to Val in At2g28000.
The isp-1 mutant bears a missense mutation in the Rieske iron sulphur protein (ISP), a subunit of the mitochondrial complex III.
Transgenic mice expressing the activated rat c- neu (with deletion mutations) bear mammary tumors with elevated co-expression of the mutant c- neu/ ErbB2 and the endogenous mouse ErbB3-encoded protein [ 32].
However, since arginine and threonine are both strong polar residues, whereas methionine and tryptophan possess bulky hydrophobic side chains, and cysteine is a weak-polar residue prone to various post-translational modifications, the R649W, T651M, and R655C mutations bear the possibility to interrupt the association between the protein and other protein partners or incur unexpected modifications.
43 LS mutation carriers bear an innate defect of their MMR machinery for which no cure is in sight.
The number of offspring of each intratumour clone was a function of the clone's relative fitness within the tumour, as determined by the number of driver and housekeeper mutations borne by the clone; this gave the model a Wright Fisher type construction.
Of note, 81.8 % (9 of 11) of CDKN2A mutations and 84.6 % (11 of 13) of TP53 mutations bore the UVB-signature.
Mutations at each locus within a particular class (driver, housekeeper, passenger and mutator, respectively) were assumed to be equivalent, so it sufficed to track only the total number of mutations borne by each cell in each class of genes.
The most obvious difference in the mutations borne by these elements is that in the internal deletion mutant both ORF1 and ORF2 are likely inactivated, whereas only ORF2 is inactivated in the other two.
We have devised a way to prepare mixed dimers, in which only one chain bears a desired mutation, or each chain can bear a different mutation.
