Sentence examples for mutations based on a from inspiring English sources

We have chosen to define true mutations based on a conservative interpretation of the data.

This value closely resembles the number of mutations based on a more limited data set [ 61] and our data further validates this number.

In contrast to simulating a random mutation spectrum, it synthesizes diploid genomes with germline and somatic mutations based on a realistic model.

Rather than considering the information of gene mutations based on a population of patients, we for the first time determine the values of the selective advantage of cancer cells and initial mutation rate for individual patients.

We have developed sensitive and specific assays for detection of the seven most common KRAS mutations based on a novel methodology named Competitive Amplification of Differentially Melting Amplicons (CADMA).

However, it is consistent with the prediction of roughly equal prevalence of BRCA1 and BRCA2 mutations, based on a survey of very early onset breast cancers (Peto et al, 1999).

Inclusion of an estimate of mutation based on a sample size of one should be clearly inadequate to anybody including Amos!

Four amino acid residues (L17, F119, L167, and L266) in the hydrophobic substrate-binding pocket of the lipase were selected for mutation based on a structural model of a substrate enzyme complex, and a combinatorial mutation library was constructed by SIMPLEX and screened for (R) and (S -configurations of p-nitrophenyl 3-phenylbutyrate.

The c.866C>T (p.T289M) variant in patient LH7 was reported as a pathogenic mutation based on a study of Italian patients [22], although it was predicted to be benign by Polyphen and tolerated by SIFT.

The BRAF inhibitor vemurafenib was approved in the United States in 2011 for patients with previously untreated, unresectable, or metastatic melanoma harboring the BRAF V600E mutation based on an improvement in OS versus DTIC in a phase III trial.

The traditional view cannot explain this association well, because this view requires an immediate benefit for the spread of a mutation based on an advantage that it supposedly brings in and of itself, whereas the "benefit" from the presence of these hotspots is due to changes that they bring in the evolutionary long-term, and which are part of the evolution of the population as a whole.