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Sequencing of dissected mutated ovaries showed many mutations at the designed targeting site.
Digenic retinitis pigmentosa due to mutations at the unlinked peripherin/RDS and ROM1 loci.
We here examine factors that systematically promote non-conservative mutations at the proteome level.
WSKV mutants exhibited mutations at the sites appropriate for the Mabs used in their selection.
Thus, mutations at the interaction surface decreased both DN synthesis initiation and processive elongation activities.
About 60% of familial ovarian cancers are associated with mutations at the BRCA1 locus.
β-Thalassemia is a disorder caused by mutations at the hemoglobin β-gene (HBB) locus.
Of the 25 pups that were injected, 9 (36.0%) showed indel mutations at the Kith-1 locus, but no pups carried any mutations at the Kith-2 locus (Fig. 3e; Table 3).
A similar effect was observed by introducing mutations at the same positions in the genotype 2a JFH-1 strain34.
Of the 38 two-cell developed and PCR-amplified embryos, 5 (13.2%) showed various indel mutations at the targeted loci.
Second, the crossreactive CK157 accumulated numerous surface-exposed FWR mutations at the dimerization interface between the VL and VH chains.
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