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One example of this is the acquisition of mutations at site R190.
Mutations at site 179 seem to interact with NRTI mutations at site 74 (graph (q)).
No mutations at site 2617 in domain V of the 23 S rRNA gene were observed.
This has also been observed in blue shifted RH1 mutants with mutations at site 90 [ 51- 53].
Changes in both the electrostatic properties and the propensity to form alpha-helix characterize drug-resistance mutations at site 210.
The two M6 matrilines completely sequenced, harbor the characteristic group defining mutations at site T16231C, T16362C and C3539T.
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But the major branches of the Y chromosome family tree are defined by mutations at sites that change very seldom.
During the evolutionary timeframe examined, the sodium-potassium pump of insects feeding on dogbane and milkweed underwent 33 mutations at sites known to affect sensitivity to cardenolides.
Not only does polη replicate past thymine dimers in DNA, but — unlike the other specialized DNA polymerases — it also correctly inserts adenine residues29, thereby preventing mutations at sites of thymine dimers.
Of these, the most commonly isolated suppressor was one that had acquired mutations at sites M58V and R190C.
Mutations at sites 100, 101, 181 and 190 are well known to contribute to resistance.
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