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The data suggested that vaccine escape mutants have derived from only few mutations at several antigenic sites.
It was already at this point that we have discovered that mutations at several, previously unnoticed sites contribute to drug resistance.
Interestingly, however, all amplifications showed multiple mutations at several discrete stages of ploidy intermediate between all copies and only one copy of the amplified region.
We noticed that mutations at several sites resulted in amino acid changes, which were maintained in influenza proteins for a relatively long time.
Finally, mutations at several genes are known to lead to pathological changes in recombination (Niedzwiedz et al. 2004; Liebe et al. 2006).
This study showed that in South Asian regions, most antigenic variations of the FMDV serotype Asia1 come from very few mutations at several antigenic sites.
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Further, we modeled the proband-specific NPARM mutation introduced at several stages of mouse hindbrain development.
These are derivatives of the previously developed strain 8C-YUNI101, which allows concomitant measurement of mutation rates at several loci.
As a complementary study, we analysed the mutation extraction performance at several mutation frequency thresholds.
Several mutations were detected at several parts of the amplicon from 21 positive samples.
Coupled with the fact that such mutations were observed at several discrete levels of ploidy, these data suggest that the genomic rearrangements driving the amplifications in these patients were acquired over a relatively protracted period of molecular time.
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developments at several
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mutations at early
mutations at residue
mutations at molecular
mutations at exposed
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mutations at specific
mutations at high
mutations at hydrophobic
mutations at polymorphic
mutations at other
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