Sentence examples for mutations at one from inspiring English sources

That is large mutational many mutations at one locus, that place a population closer to long-term equilibria may be lost because the appropriate trait values at the other locus do not yet exist.

To address this problem, we have extended the K a / K s concept to consider interactions with other sites, by formulating a conditional K a / K s that measures the effects of mutations at one site on the selection pressure for mutations at another site.

However, the tRNA-Tyr genes do not mutate at equal frequency; mutations at one locus (SUP6-o) represent 31% of the ochre suppressors, whereas two other loci (SUP2-o and SUP8-o), each account for only 2% of the suppressors, suggesting that the rate of GC to TA transversions is nonuniform across the yeast genome (Ito-Harashima et al. 2002).

For example, when we transformed a multiply-mutated fragment into a strain, the frequency of incorporating mutations at one end was approximately was four-fold higher than the frequency of incorporating mutations at the other end.

X-ray crystallography showed interactions between the RING and C2HC ZnF, whilst mutations at one of these contact residues, M112, resulted in an inhibition of ubiquitin ligase activity, elucidating an important structural role of the C2HC ZnF.

Six mice generated with tru-RGNs of tF7 3 carried off-target mutations at one predicated site (OT3 2, Fig. 2B; Supplementary Table S2), with its off-target ratio of 29.3% in mutant mice versus newborns (n = 20).

It relates to (intragenic) epistasis: the selection coefficient of a mutation at one site depends on the states at other sites.

The functional topology of sequence space depends strongly on the degree and type of epistasis, defined as genetic interactions between sequence sites, such that the effect of a mutation at one site depends on the state at others.

This resistance to APC was first characterized by Dahlbäck and coworkers [ 21] and derives from a mutation at one of the APC inactivation sites (Arg → Gln) on FV/FVa rendering it resistant to APC cleavage [ 22].

A mutation at one of the contact residues in the C2HC ZnF, a highly conserved M112, resulted in the loss of ubiquitin ligase activity.

No germline mutations could be identified in the breast cancer families and only one sporadic carcinoma carried a PTEN mutation at one allele.