Sentence examples for mutations at less from inspiring English sources

This could bias the mutational spectrum of a gene towards micro-adaptive changes, as mutations at less important sites are more likely to produce functional proteins with slightly altered optima.

It follows that mutations at less critical residues might cause corpus callosum and cerebellar malformations without obvious LIS, as we now document in one patient.

In contrast to QMC-PCR and COLD-PCR, Sanger sequencing does not detect mutations present at less than 20% of total DNA [ 8, 9].

Naturally occurring mutations at no less than six locations on this loop, of which two ablate s7, lead to albino phenotypes, and models indicate that M374, S375 are involved in catalysis [52].

In recent years, highly sensitive assays have been developed that detect HIV-1 drug resistance mutations when present at less than 1% of the viral population.

Simultaneously, viruses with mutations at F317 were less infectious, possibly due to the contribution of F317 to optimal formation of the V3 hydrophobic core.

Simultaneously, viruses with mutations at F were less infectious, possibly due to the contribution of F to optimal formation of the V3 hydrophobic core.

Second-site suppressor mutations at Val510 to less hydrophobic residues such as aspartic acid may reverse the alteration in the local structure of the protein caused by the ΔF508 mutation or prevent intermolecular interactions that lead to retention in the endoplasmic reticulum or increased turnover at the cell surface.

Interestingly, while WT 4RTau isovariants are displayed over a wide range of isoelectric point (pI) at mainly L1 molecular weight, isovariants for P301S and S305N mutations are found proportionally at less acidic pI and at higher molecular weight (L2 and L3).

In four out of five human data sets and one chimp set, nonrandom mutations at distant sites were less likely to be linked than nearby mutations--implying recombination between maternal and paternal DNA, says Eyre-Walker.

This subtype is associated with valosin-containing protein (VCP) mutations, and is very rare at less than 1% of familial FTLD.