Sentence examples for mutations at conserved from inspiring English sources

Because KCNQ1 and HERG are highly conserved, an underlying neutral mutational process could produce large numbers of mutations at conserved sites.

Because the amino acid sequences of HERG and KCNQ1 are highly conserved (over 65% complete identity between fish and human sequences in both channels for the regions used), a neutral mutational process would still produce a large number of mutations at conserved sites.

These alleles include many with diverse functional effects such as premature stop codons, aberrant splicesites and mutations at conserved active site residues.

Sequencing of the Bc28.1 genes from 4 genetically distinct B. canis laboratory strains (A8, B, 34.01 and G) revealed 20 mutations at conserved positions of which three allowed the classification of B. canis strains into three main groups (A, B and 34.01/G) by RFLP.

Mutations at conserved sites between LATS1/2 such as LATS1-F1015/LATS2-F978, R1020/R983, F1039/F1001, and D1086/D1048 may affect function of the C-terminus.

Here we show that mutations at conserved cysteine ligands for the Pri2 Fe-S cluster markedly decrease the protein stability, thereby causing S phase arrest at the restrictive temperature.

This paper analyses, using a panel of well-characterised Mabs, the effects on the antigenicity of various C- and N-terminal deletants of HPV-16 L1 made in insect cells via recombinant baculovirus, of an A → T mutation at residue 266 (and6T), and of a C → G mutation at conserved position 428 (C428G).

To improve our understanding of the lack of pH-induced changes in the HS EPR spectra as well as the difference in ferric heme signals of the various Clds, structurally conservative mutations at highly conserved Trp and Tyr residues within hydrogen bonding distance of the heme propionates were constructed.

To address the function of Scc3's most highly conserved domain, we created a series of mutations at highly conserved positions (Fig. 5A and B).

These mutations all occur at conserved amino acids, and cluster at sites likely to stabilize the closed (inactive) conformation when placed on the crystal structures of AP2 (Collins et al., 2002; Kelly et al., 2008; Jackson et al., 2010).

A number of other NS5A mutations at relatively conserved sites were also seen in one of the four resistant lines; these are not known as adaptive mutations that generally enhance replication.