William Harbour, Anne Bowcock and colleagues identify recurrent mutations at codon 625 of SF3B1 in uveal melanomas.
K-Ras mutations at codon 12 play an important role in an early step of carcinogenesis.
Mutations at codon 215 were present in 82% of all patients at baseline and in 87% after therapy.
Using viral variants with single point mutations at codon 184, we measured the impact of these mutations on virus replication.
Mutations at codon 315 in the katG gene encoding catalase-peroxidase (KatG) are the major cause of INH resistance in MTB.
Chartier-Harlin MC, Crawford F, Houlden H, Warren A, Hughes D, Fidani L et al. Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene.
Furthermore, in those infants born in 1998 1999, there was a trend toward an increase in the frequency of zidovudine resistant mutations at codon 215 corresponding to an increase in maternal zidovudine treatment.
All patients with additional RAS mutations had progressive or stable disease, except 3 patients with mutations at codon 61 of KRAS or NRAS who experienced partial (2 cases) or complete response.
Objectives: The purpose of the study was to investigate the occurrence of mutations at codon 215 in HIV-1 infected infants and its association with clinical status and virological parameters.
The mutant-enriched PCR technique (ME-PCR) was used to amplify and detect point mutations at codon 12 of the c-Ki-ras oncogene.
In comparison, the hazard ratio when comparing adjuvant chemotherapy with observation in the patients with KRAS mutations at codon 12 was 0.95 (95 % CI, 0.77 1.44, p = 0.77).
