Sentence examples for mutations at all from inspiring English sources
Mutating Trp107f to Ala reduced pyruvate activity by five orders of magnitude, whereas mutations at all other positions had effects less than a single order of magnitude, including the canonical specificity residue at position 102.
Thus, it is not clear if filament properties are affected by these mutations at all.
We expand earlier mathematical forms to include epistasis, or interactions between mutations at all pairs of loci.
We generated a cysteine-less form of hASBT by creating point mutations at all 13 endogenous cysteines in a stepwise manner.
Since engineering new substrate specificity (gain of function) into enzymes is often complex and mutations may require a specific constellation of multiple residues to result in a functional change52,53, we created an MphI library with mutations at all four positions, in combination, using combinatorial site-saturation mutagenesis.
We further constructed a five-point mutant of LinBUT (A112V/I134V/I138L/A247H/M253I: M5-1) (Figure 4o), which has the mutations at all five amino acid residues that were suggested to be important for β-HCH degradation activity.
Subtype N9 from the NCBI data set did not have any mutation at all.
By modelling the effect on receptor binding of each mutation at all thirteen sites that differed between A/Panama/2007/99 and A/Fujian/411/02 viruses (Fig. S3 and Fig. S4), we found that the mutations at residues 222 and 225 played the most important role in mediating receptor binding alterations in the Fujian-like viruses (The detailed analysis is given in the legends of Fig. S3).
Standard error is presented for each site and mutation at all temperatures.
One patient in this study carried the KRAS p.G12D allele in an implant though no KRAS mutation at all was detected in the corresponding s-BOTs.
If each homologous chromosome bears one new mutation, the crossing-over may create two daughter chromosomes, one with the two mutations, and the other with no mutation at all.
