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ActiveDriver is able to detect significantly mutated functional sites in cancer genome providing an analysis of the somatic mutations associate to phosphorylation signaling.
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Several gating properties are affected by alternative splicing, C-terminal truncations and mutations associated to idiopathic epilepsy.
Approximately half of the patients harbor two CEPBA mutations associated to a favorable prognosis.
Table 1 shows the distribution of mutations associated to articles in each database.
We evaluated nine different natural mutations associated with Haemophilia B deficiency (Fig. 1A) and seven mutations associated to CF (Fig. 1C).
However, this may require time due to the size of the mutations associated to the central CORE.
Detection of mutations associated to antiviral therapy and HBV genotyping are essential for monitoring treatment of chronic hepatitis B patients.
On the other hand, values of selection coefficients against deleterious mutations could not be comparable to mutations associated to TE insertions.
TP53 null tumors constitute a specific subgroup characterised by nonsense, frameshift or splice-site mutations associated to complete absence of p53 expression.
Forty-one of the 57 (72%) observed mutations occurred at this locus, and when mutations associated to this locus were removed from the combined data set, the mutation rate (excluding O157-10) decreased noticeably (6.9 × 10−04 mutations/generation).
All considered, we set forth to examine ΔNp63 α acetylation in the context of naturally occurring ΔNp63 α missense mutations associated to SHFM-IV: one such mutation causes lysine 193 substitution with glutamic acid (K193E) (7, 8).
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