Sentence examples for mutations as we from inspiring English sources

"The cells will carry as many mutations as we want to study.

Additionally, recombination may occur with similar but not identical endogenous sequences, leading to unexpected mutations, as we found in human tripronuclear zygotes in which HBB recombined with HBD (Liang et al., 2015).

We did not have false negative in the eight patients with known mutations as we retrieved all mutations.

We speculate that in IDH mutant chondrosarcoma the acquisition of additional mutations as we have shown here have facilitated their growth in culture.

Another interesting aspect is to combine edge and node perturbations in Boolean network models to reveal edgetic mutations, as we did in the HCC1954 cell line for AKT.

It will be interesting and important to extend these observations to cells expressing other TRAPS-associated TNFR1 mutations, as we are currently doing for the R92Q variant of TNFR1 (Abduljabbar et al., in preparation).

We validated the array on patients with previously known mutations as well as unaffected controls, we identified three novel pure intronic rearrangements and we defined all the mutation breakpoints both in the introns and in the 3' UTR region.

In addition, we observe mutations as late as 92 weeks after the onset of symptoms and just after the cessation of therapy (eg C1 NS5B) within published HLA-A and -B-restricted epitopeS1(Table S1), indicating ongoing immune pressure or compensatory mutations late in infection and during or after interferon treatment.

Specifically, we studied single residue mutations as well as complete unbiased designs of a hexapeptide substrate.

If they reversed these five mutations as well, the new receptor behaved like an old one.

Moreover, our data challenged the hypothesis of FGFR1 as a driver mutation as we were not able to detect any FGFR1 amplification in small tumours (T1).