Sentence examples for mutations as revealed from inspiring English sources

Sequences that grouped with vaccine strains or within African genotypes (Supplementary Figures S1 and S3) and divergent sequences that appeared to have accumulated excessive mutations, as revealed by the linear regression analysis of the root-to-tip distances against sampling time method implemented in Tempest32, were removed.

Our EM analysis revealing that the NECD forms a dimer and adopts distinct conformations now opens the way to correlate the functional state of mutations as revealed by genetic analyses to the receptor structure.

Furthermore, NMR studies of M13V and M13V/K22M have shown that the CXXCH peptide is rigidified by these mutations as revealed by hydrogen exchange.

Saturation mutagenesis at each of the six positions did not result in enhanced thermostability in almost all the cases, confirming the crucial role played by each mutation as revealed through the structural study.

TALENs for Psf2 and Sld5 were able to generate mutations effectively, as revealed by HRMA, but many of the G0 individuals died as pupae.

Furthermore, genetic analysis of the generated tumors reveals mutations, as well as amplifications at genetic loci commonly affected in medulloblastoma, such as Ptch, c-myc, n-myc and p53 (17, 94).

Nonetheless, this method revealed its limitations in identifying potential non-coding mutations (promotor, intron) or large deletions, as revealed by our inability to detect the heterozygous mutations in patients F6 and F12 [ 1] and the need to use CGH array for large deletion (patient F25 [ 16]).

The higher mutagenesis level in diploid cells is due to recombination events, including gene conversion, crossover or chromosome loss, as revealed by mutation spectra analysis (Hiraoka et al. 2000; Ohnishi et al. 2004).

Thus further analyses for genomic rearrangements in Asian populations may reveal additional CHEK2 mutations as well.

Here, we show striking intratumoral clonal diversity within FL tumors in the representation of mutations in the majority of genes as revealed by whole exome sequencing of subpopulations.

Perturbations of this fine-tuned network can lead to leukemia, as revealed by hypomorphic mutations of CEBPA or of SFPI1 in acute myeloblastic leukemia and by the involvement of RARA or rarely of RARG in chromosomal translocations in acute promyelocytic leukemia.