Sentence examples for mutations as demonstrated from inspiring English sources

Moreover, subtypes may be operating under different evolutionary pressures when acquiring specific drug resistance mutations, as demonstrated for the D30N NFV-associated mutation in subtype C [11].

Alternatively, an increase in transcription may simply increase the level of spontaneous mutations as demonstrated in certain bacteria [ 18].

A less invasive strategy involves the manipulation of the domains' specificity by point mutations as demonstrated by Eppelmann et al. [ 10] for the A domain.

Since the M64T and R76P CaM-NLS mutants show essentially normal DNA-binding and -bending activities [ 9, 10], the only detectable effect of the mutations, as demonstrated for the first time, is impaired CaM binding and consequently impaired nuclear import.

The two loxP sites are in direct orientation and therefore permit excision of the gene trap leading to reversion of the mutations, as demonstrated for GBT-R15 mutations in gabbr1b and tnnt2 genes [ 27, 28].

This is of particular significance because it means that pyridomycin can effectively kill isoniazid-resistant M. tuberculosis carrying katG mutations as demonstrated by our susceptibility testing of isoniazid-resistant clinical isolates.

The EPOR G1251T mutation segregated with the polycythemic status, as demonstrated by the EPOR analysis of other family members (Figure 1B).

Integration can result in an insertional mutation, as demonstrated in the transposon section (see below).

We show repair of the alb b4 mutation, as demonstrated by the appearance of pigmented cells in the larvae, when wild-type donor DNA is co-injected with the CRISPR/Cas system at the one-cell stage.

In addition, defects in autophagy may allow accumulation of chromosomal instability and genomic mutation, as demonstrated by the higher rates of gene amplification and DNA damage observed in renal (Mathew et al, 2007) and mammary epithelial cells in response to metabolic stress when both apoptosis and autophagy were suppressed (Karantza-Wadsworth et al, 2007).

Right/Left K - Look as demonstrated.