Sentence examples for mutations as a consequence of from inspiring English sources

These sequence motifs are known to be mutational hot spots for insertion deletion mutations as a consequence of slip-strand mispairing during replication (Denver et al. 2000, 2004; Fan and Chu 2007).

In addition, immunotherapies targeting multiple regions of the viral genome have the potential to force the accumulation of multiple mutations as a consequence of polyvalent CTL pressure which can drive the virus into a state of poor replicative fitness [31].

We used here an experimental set up starting from a SI strain grown under permissive conditions and transferred to non permissive conditions to select for loss of function mutations as a consequence of the plasticity of the WD repeat domain of the hnwd gene family (figure 1).

These findings do not preclude the eventual involvement of APC loss and consequent increase in Wnt/β-catenin signaling in the development of Cr VI -induced intestinal tumors that might result from gradual aCr VI -induced mutatintestinalconsequence of chronic intumorsal injury.

Subculturing produces a bottleneck of 6 10 cells per subculture, a population size that should be sufficiently large to prevent the fixation of deleterious mutations as a consequence of drift, suggesting that these substitutions between the strains are either neutral or advantageous in the lab environment.

The existence of this selection pressure operating independently of DNA methylation induced mutation is supported by our finding of mutational biases against CpG dinucleotides among RNA viruses in which conventional deamination and mutation as a consequence of methylation cannot occur.

The second mouse had been bred with a specific genetic mutation, as a consequence of which it could hear nothing and had no sense of balance.

The immune escape mutation (as a consequence of a true mutation or a re-assortment [19]) generates a new antigenic cluster called the mutant.

The paternally inherited 6q24 duplication is likely to be the etiological mutation as a consequence of overexpression of paternal genes within the duplicated chromosome 6q24 region.

In some cases, strains susceptible to levofloxacin but with a first-step parC mutation, as a consequence of previous quinolone use, were present before therapy was initiated.

Our likelihood engine evaluates an HMM transducer switching between fast and slow states, where the evolutionary models in the slow states indicate a reduced rate of mutation as a consequence of purifying selection.