Sentence examples for mutations around the from inspiring English sources

But most mutations are neutral in their effect.Sexual reproduction mixes up the DNA, distributing neutral mutations around the population.

Moreover, computational modeling shows that stem cell arrangement and positioning of axillary meristems distribute somatic mutations around the main shoot, preventing their fixation and maximizing genetic heterogeneity.

The largest improvements in display resulted from mutations around the junction between P8 and the C-terminal linker, and additional mutations in the N-terminal region were selected for further improvements in display.

These studies showed that, at least for APP, cleavage requires a membrane anchor and most mutations around the scissile bond decrease processing.

Interestingly, at day 15 post-infection with the AP-1 mutant viruses, we observed the emergence of a low percentage (5 to 10%) of viruses that reverted to the wild-type sequence or that harboured additional mutations around the AP-1 sites possibly to counteract the negative effects of the intragenic AP-1 sites mutations on viral replication.

3) Alternatively, the U can be recognized as a U G mismatch by the mismatch recognition complex Msh2-Msh6, resulting in exonuclease 1 (Exo-1) activation, formation of a single-stranded gap, activation of Rad6/18, PCNA-Ub and recruitment of the TLS polymerase η (Pol η) to generate 90% of all A/T mutations around the initial mismatch [16], [17], [18], [19], [20].

These results are consistent with local adaptation; however, there was limited evidence for the signal of recent 'hard' selective sweeps from new mutations around those sites in the local samples.

We were particularly interested in point mutations clustered around the central hydrophobic core of Aβ (E22G Arctic mutation, E22K Italian mutation, D23N Iowa mutation, and A21G Flemish mutation) (Fig. 1).

To explore whether there was serial selection of mutations in these epitopes, i.e. whether the first escape mutation served as a baseline form for added selected mutations, we grouped all variants of each major escape form as a lineage, and tested whether or not the frequencies of secondary mutations around each of the most-common selected mutations were Poisson-distributed.

In contrast to FUS/TLS, however, solid evidence for nuclear transport deficits related to TDP-43 mutations is lacking as none of the mutations cluster around the NLS or directly affect its sequence (112).

In nonsmall cell lung cancer (NSCLC), EGFR mutations cluster around the tyrosine kinase domain (ATP-binding pocket; exons 18 21) and some of these mutations are associated with increased sensitivity to EGFR-tyrosine kinase inhibitors (EGFR TKIs) such as gefitinib, erlotinib, and afatinib; these drugs have been approved for treatment in advanced NSCLC with sensitive mutations [ 18– 23].