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A full 80% of the microsatellite mutations arising within the [TC/AG]20 allele were expansions.
Clearly, single nucleotide mutations arising within genomic DNA can lead to the creation of TFBSs.
Mutations arising within cis-regulatory elements can generate variation in downstream genes expression by changing the way transcription factors or ribosomes bind.
In the absence of recombination, beneficial mutations arising within different individuals compete with one another, in a process referred to as clonal interference (Fisher 1930; Muller 1932).
We now suppose that the population is divided into subpopulations by the use of neutral markers, with each initial haplotype having a single marker, and subsequent mutations arising within distinct subpopulations.
Here therefore, the Illumina® Solexa platform [ 22] was used to define a comprehensive inventory of mutations arising within the P. chabaudi drug-resistant lineage (Methods, Additional File 7) and specifically, to determine the presence of other mutations on chr02.
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Wagner based his method on the probability p(di,k) that, under the null hypothesis that all sites are equally likely to be mutated, k mutations arise within di,k or fewer residues, starting at the position of mutation i.
Instead of building our algorithm on the probability that, under the null hypothesis, k mutations arise within n or fewer residues, we consider instead the probability that k or more mutations fall within exactly n residues.
Eight point mutations arise within the mutant lineage, only one of which appears on chromosome 2.
We hypothesise that during the course of infection numerous genetic mutations arise within a mycobacterial population and in response to a selective pressure such as antibiotic exposure, clones with pre-existing drug resistant mutations are selected.
Unique breed predilection suggested the mutation arose within the Beagle gene pool.
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