Many of these early researchers focused on the seemingly random process of mutation, arguing that adaptation was an incidental or accidental byproduct (e.g., mutationist theory of de Vries).
We note that the level of expression of components of the Dnmt3 complex was not significantly altered by the D124A mutation, arguing that the observed methylation defects could not be attributed to reduction in the expression levels of these proteins.
This age-dependent increase in splenic B-1a IgVH mutation argues that the detected SHM is not due to contamination with co-sorted B cells of other subsets, including GC cells, i.e., cells with the germinal center phenotype (GL7+ CD38lo CD95hi) are not detectable in the splenic B-1a population.
Entine, author of the new book "Abraham's Children: Race, Identity and the DNA of the Chosen People," argued that genetic mutations gave Jews very high IQs.
Given that repair by gene conversion would rely on a break of the DNA, the lack of kataegic mutations argues against a mechanism that would require breaks in association with MELs.
Statisticians could argue that point.
No one argues that point.
But Henry L. Niman, a biochemist who tracks flu mutations, was skeptical, arguing that human immune systems would have long ago eliminated flu were the virus as vulnerable in one spot as this discovery suggested.
Henry L. Niman, a biochemist who tracks flu mutations, was skeptical, arguing that human immune systems would have long ago eliminated flu were the virus as vulnerable in one spot as this discovery suggested.
Although mutations might be more easily detectable in cell lines because of their homogenous nature, the substantial increase in mutation frequency argues that Notch mutations become enriched in multiple tumor cell lines during in vitro culturing.
