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Still, PI resistance mutations are widespread and even present in naïve patients [10], [11], [12], [13], [14], [15], indicating that monotherapy with PI may select for resistance mutations already present at baseline of treatment [6], [16].
Thus, individuals with small mitochondrial DNA deletions present at low heteroplasmy levels would not present clinically with symptoms, which is consistent with the observation that potentially pathogenic mitochondrial DNA mutations are widespread in the non-diseased population but at sub-threshold levels (Elliott et al., 2008).
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If the lower than expected proportion of parallel evolution for nonsynonymous sites holds up, this manuscript will be additional evidence that mildly deleterious evolution of nonsynonymous mutations is widespread.
Oncogenic mutations in KRAS are widespread in human PanINs and detected in in over 90% of human PDA [ 3– 6].
Although global levels of K36 methylation appear unaffected, this mark is reduced on nucleosomes bearing G34R/V mutations, and there clearly are widespread changes in K36 methylation profile of the G34V glioma cell line analyzed (Bjerke et al. 2013) (which may be indirectly caused by the altered transcriptional program of these cells).
Such concerns are widespread.
White sharks are widespread.
Sand dunes are widespread.
Statistical mistakes are widespread.
Yet difficulties are widespread.
Municipal libraries are widespread.
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CEO of Professional Science Editing for Scientists @ prosciediting.com