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Overall, MxA single-point mutations are widely spread in different human cancers, and MxA mutates more frequently in colorectal cancer according to current data.> -wrap-foot> aR655C mutation was discovered in colorectal cancer in two individual sequencing projects We then checked the conservation level of the amino acid residues mutated in cancers.
Activating mutations in one allele of an oncogene (heterozygous mutations) are widely believed to be sufficient for tumorigenesis.
While mitochondrial DNA (mtDNA) mutations are widely used in evolutionary studies, they also play a central role in apoptosis, disease and aging [1], [2].
The A*33-associated T242X and G248X mutations are widely known to be selected by HLA_B*57/*5801 [26], so they are likely to be reflected in the linkage disequilibrium with B*58.
These mutations are widely scattered across both genes.
The mutations are widely distributed along the entire protein without a dominant location.
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Genetic testing to identify BRCA1/2 mutations is widely available and commonly employed.
In fact, in the RIM+ alleles tested, six point mutations were widely scattered along the protein.
Parasites carrying the 581G mutation are widely distributed in Tanzania (figure 5) and elsewhere in Africa (figure 6).
S315T-MtKatG mutation is widely reported for INH resistance.
Of the 142 mtDNAs analyzed, 74 were categorized into macro-haplogroup M, and the rest 68 pedigrees' mtDNAs were assigned to macro-haplogroup N. mtDNA haplogroup distribution analysis showed that 1555A>G mutation was widely dispersed among 11 major Eastern Asian haplogroups D, M7, M8, M10, M11, G, F, B, R, A and N9 (Fig. S2 and Table S2).
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