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The functional effects of these deletions on parasite growth and response to CQ or PfCRT mutations are unknown.
Two criteria were used to identify unique mutations possibly acquired by these sequences after their insertion into the nuclear genome: (i) such unique mutations are unknown in mtDNA of other species and (ii) they have functional effects on encoded mitochondrial proteins.
The genetic events underlying bm2 and bm4 mutations are unknown.
However, in many POF cases, the underlying genetic variants or mutations are unknown.
In other histological tumour types, PDGFR-α-activating mutations are unknown [ 29].
A further obstacle for the interpretation of large-scale somatic mutation analyses is that fitness effects of the vast majority of mutations are unknown.
Similar(50)
The precise incidence rate of SDH mutations is unknown.
However, the mechanism linking these alterations to CLDN14 mutations is unknown.
The functional importance of these mutations is unknown.
The precise effect of these mutations is unknown.
The biological significance of these mutations is unknown.
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