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Even though the biological significance of missense and silent mutations are uncertain, the mutational spectra of the APC gene may provide a more complete picture of impact and type of carcinogenic exposure.
It is believed that reverse mutations to subtype consensus are widely observed during the early phase of HIV-1 infection [2], [13], [15], [18], [19], although quantitative and timing relationships between reverse and escape mutations are uncertain.
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The significance of uncommon mutations is uncertain.
The pathophysiology of olfactory identification loss in both nonmutation PD and related to LRRK2 G2019S mutations is uncertain.
The neuropathological spectrum of PD brains harboring VPS35 mutations is uncertain since no mutation carriers have yet come to autopsy (9).
One previously published case (Patient 12, Fratter et al., 2011) was omitted from the current analysis, as the pathogenic nature of the reported heterozygous mutation was uncertain after segregation studies.
The estimates for the dhps double mutation alone are uncertain (as demonstrated by the wide credible intervals) since almost all samples which contained the double mutation also contained the triple dhfr mutation.
As with any diagnosis linked to newly characterized genes, prognosis and the full range of phenotypes for patients with homozygous or compound heterozygous CHMP1A mutations are currently uncertain.
In many instances, acquired mutations are missense mutations whose functional consequences on TET protein activity are uncertain.
The molecular mechanisms of this activation are uncertain, but do not involve demonstrable mutations in β-catenin or Axin, unlike HCA [10].
Postwar recollections are uncertain.
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