Sentence examples for mutations are unable from inspiring English sources
We also find that suppressor mutations are unable to supress lethality in null animals.
These findings indicate that the vinculin Y1065 mutations are unable to significantly disrupt head tail interactions in the context of the full-length protein.
BRCA1 transgenes with E3 ligase mutations are unable to restore HR in BRCA1 defective cells using I- SceI based HR reporters detecting GC [ 91, 94].
Mutants carrying the a mutations are unable to generate the α factor, since they never present Anneau morphology and cannot be infected by that factor.
Families without detectable APC mutations are unable to benefit from the use of genetic testing for clinical management of this autosomal dominant syndrome.
Since we expected these mutants would mirror the F539D mutation and also exhibit constitutive activity, their loss-of-function phenotype suggests that the CARDs bearing these combined mutations are unable to transduce the activation signal to MAVS.
Likewise, while point mutations were unable to disrupt CMG formation as judged by co-immunoprecipitation, a quadruple Psf1 mutant (E190A/L192A/V193A/R194A) proved unable to interact with Cdc45.
Although the alanine mutations of either Y6/8 or ELV did not substantially reduce the binding, the mutant combining both sets of mutations was unable to bind AP1.
However, as determined by the neutralization assay, in some cases MAR mutations were unable to confer antibody escape to the virus and thus behaved as recessive alleles.
Many of these mutations were unable to restore respiratory competence in m-AAA-deficient yeast strains, providing additional evidence for their deleterious nature in humans (Di Bella et al., 2010).
SHP-2 tyrosine phosphorylation was dependent on DDR2 kinase activity, as HEK-293 cells expressing either control vector or a kinase-dead version of DDR2 (either K608M or K608E mutations) were unable to phosphorylate SHP-2 when cells were exposed to collagen I. Taken together, these data indicate that SHP-2 is a downstream effector of DDR2 activation.
