Sentence examples for mutations are thought from inspiring English sources

Few secondary mutations other than T790M have been identified to date and include D761Y, L747S, and T854A; these non-T790M mutations are thought to occur in <5% of EGFR-mutated TKI-resistant patients 43.

Because beneficial gene mutations are thought to be exceptionally rare, the scientists postulated that the bugs' speedy adaptation must rely on something else.

Within each class mutations are thought to be sex-specific.

SPINK1 gene mutations are thought to diminish protection against prematurely activated trypsin, and are thereby linked to trypsin-related pancreatic injury [10], [15].

These mutations are thought to increase the amount of Aβ42 polypeptide produced relative to another non-toxic APP cleavage product, the Aβ40 polypeptide.

Though multiple proto-oncogenes and tumor suppressor genes play an essential role in neoplastic growth, no more than 15 somatic "driver" mutations are thought to be responsible for individual cancer initiation, progression, and maintenance.

The Ras gene mutations were thought to activate multiple signaling pathways leading to cell proliferation (Maruta & Burgess, 1994).

The loss of α-MSH-mediated activation in the human MC4R mutations is thought to be the basis of the obesity in patients carrying these mutations.

Second, the underlying mechanism of FTD associated with progranulin mutations is thought to be haploinsufficiency [7], [8], whereas other disease proteins seem to contribute to pathogenesis, at least in part, through toxic gain-of-function mechanisms [14] [17].

Initially, KRAS mutations were thought to be uncommon in NSCLC cases without a history of smoking (Rodenhuis et al, 1987).

The effect of these deleterious mutations is thought to have different consequences for eukaryotic and bacterial genome architecture.