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"Prices are sustained.
As a result, the NFS mutations can still be sustained without major effects on protein function if the affected amino acid is non-essential for biological activity.
The rgCA04/09 virus shedding showed similar kinetics to mutant virus harboring the Ile219→Lys amino acid mutation in HA, which was sustained for 5 days in ferrets at titers of ≥104.3 PFU/ml.
Because SCZ must be sustained by mutation-selection balance without heterozygote advantage in the NGM and the mutation rates in the nuclear genome are much lower than in the mitochondrial genome [ 12- 14], the criterion is strong.
Substantial evidence of epidemiology suggests that nuclear susceptibility genes, if present, should be sustained by mutation-selection balance without heterozygote advantage.
Then, pathogenic but neutral or almost neutral genes in ancient environments could be fixed at a high frequency close to 1 by genetic drift (because the effective population size might be much smaller and the effects of genetic drift might be predominant in ancient times) and can be sustained by mutation-selection balance today.
Thus we have the criterion for a susceptibility gene: (6) d < ν, where ν is defined as ν ≡ (1 − s p ) μ (1 − p ) s p.From the observation (A5), we can see that d≥ v implies s> s M for any SCZ-associated variant M which is sustained by mutation-selection balance.
When seeding the population with individual based solutions of the minimal coding length for the evolutionary target, these full solutions can only be sustained for mutation rates up until μ = 0.126, μ = 0.110 and μ = 0.088, respectively for the targets with a length of 13, 15 and 19 elements (shown as stars in Figure 3).
Only nucleotides in regions whose alignments were sustained by compensatory mutations across the entire data set were considered as homologous.
Nucleotides in paired regions whose secondary structure was sustained by compensatory mutations across the entire data set were considered as homologous.
The objection was sustained.
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