Sentence examples for mutations are subject from inspiring English sources

These mutations are subject to weak negative selection, according to the study.

However, we show that BRCA1 mutations are subject to strong negative selection.

Such mutations are subject to 'non-stop decay' [32], [33], and would result in no gene product.

We assume that all synonymous mutations are subject to the same strength of selection.

That is, both classes of mutations are subject to interference, not genetic drift, as a dominant stochastic force.

When discussing this issue, it is important to recognize that somatic mtDNA mutations are subject to the same apparently random mitotic segregation as inherited mtDNA mutations (5).

Assuming synonymous mutations are subjected to almost strictly neutral selection, ω<1, ω=1, and ω>1 represent negative selection, neutral evolution, and positive Darwinian selection, respectively [ 65].

In principle, this somatic evolution should follow the same Darwinian logic as evolutionary processes in populations in nature: diverse heritable types arising as a result of mutations are subjected to selection, resulting in expansion of the fittest clones.

We obtained DNA oligomer frequencies at SNPs and DIMs and in their corresponding reference regions to address whether both types of mutations were subject to similar mutational hotspots.

It is also assumed that the chromosomal region harboring these mutations was subject to selection-driven suppression of recombination (Charlesworth 2013), which may have been facilitated by chromosomal inversions (Lemaitre et al. 2009; Wang et al. 2012) and translocations (Charlesworth and Charlesworth 1980).

However, the cost of profiling a cancer genome at base pair resolution remains out of range for routine clinical use, and calling mutations is subject to ambiguities as a result of tumor heterogeneity, when DNA is obtained from bulk tumor tissue.