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The effects of most mutations are strongly context dependent.
However, in non-B cells mutations are strongly biased towards guanines and cytosines, whereas in B cells, mutations are found on all four nucleotides.
In patients with NSCLC, EGFR mutations are strongly associated with EGFR-tyrosine kinase inhibitors (TKI) sensitivity.
Several genetic mutations are strongly associated with lipodystrophy, including mutations in Agpat2, Pparγ, Lmna, Zmpste24, Akt2, and Bscl2 (Agarwal and Garg, 2006).
IDH mutations are strongly associated with a wide range of transcriptomic and genomic alterations in gliomas [18].
Using UV radiation to induce mutations at the lacZ locus in proliferating mouse embryonic fibroblasts we have previously shown that point mutations are strongly dependent on mitotic activity [7].
Similar(27)
16, 23, 39 Mutational analysis for activating mutations is strongly recommended in all advanced GISTs because of their predictive value.
Mutational analysis for activating KIT and PDGFRA mutations is strongly recommended in KIT-negative tumors and in all advanced GISTs.
To access the distribution of selection coefficients for mutations in 367 East Asians, we employed the strategy referred in Tamuri et al.54 and found that ~80% of the nonsynonymous mutations were strongly deleterious with population scaled coefficient less than −10 (data not shown).
The number of synonymous mutations is strongly correlated with tree length and hence with λ i.
ACVR1 mutations were strongly associated with H3.1-K27M H3.1-K27Mously described [ 14].
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