Sentence examples for mutations are sensitive from inspiring English sources

Encouragingly, these results also indicate that various types of ALK mutations are sensitive to currently available neuroblastoma therapy.

We wanted to establish if CFC allele mutations promote the same phenotypic outcome in vivo, and which mutations are sensitive to currently available MAPK-pathway inhibitors (11, 12).

38 Other single-gene determinants with somatic mutations are sensitive to targeted therapy; for instance, active ESR1 mutations in ER-positive metastatic breast cancer.

In these cases, although such mutations are sensitive for MSI-H (Ionov et al, 1993; Dietmaier et al, 1997; and so may reflect an MSI-H-associated underlying mechanism), the singular mutated marker would result in the MSI-L classification.

Not all EGFR mutations are sensitive to EGFR TKIs; for instance, mutants at exon 20, either T790M or exon 20 insertion, are resistant while L858R and exon 19 deletion are sensitive to EGFR TKIs.

However, certain cell lines with KRAS mutations were sensitive to MEK inhibition alone [ 78].

Breast cells transformed with these mutations were sensitive to HER2 kinase inhibitors, such as lapatinib and neratinib.

The strains with eis mutations were sensitive to CAP and resistant to KAN, with MICs varying over a wide range (0.63 to 20 μg/mL).

It should be noted that malignant hyperthermia, a disease associated with RyR1 mutations, is sensitive to potassium chloride (Moulds and Denborough, 1974), and therefore a testing method in patients or biopsy samples need to be initiated prior to potassium supplementation.

Finally, the channel with E701C/E730C double mutations is sensitive to oxidation/reduction (redox) while the channels with single mutation (E701C or E730C) are not, arguing that the two introduced cysteine residues may form a disulfide bond and that E701 and E730 are thus solvent accessible and close to each other.

Interestingly, although the B7 mutation in TSA1 confers resistance to CHP, Timmermann et al. also show that cells harboring this mutation are sensitive to hydrogen peroxide.