Sentence examples for mutations are selected from inspiring English sources
However, using pairwise comparisons of genes within these groups we can show that for the majority of orthologous genes ω is small, confirming the general assumption that non-synonymous mutations are selected against and that purifying selection is the dominant force in evolution.
Ultimately, oncogenic mutations are selected from a mutated population.
In sequences that have evolved under positive selection, the number of retained mutations is closer to those that arose by mutation than under purifying selection where amino acid replacement mutations are selected against.
HBX inactivating mutations are selected in HCC tissues suggesting specific pressure of selection during hepatocarcinogenesis.
By analysing resected HCC in France, we identified specific molecular features related to HBV infection: HBX inactivating mutations are selected in HCC tissues suggesting specific pressure of selection during hepatocarcinogenesis.
That is, only few amino-acid mutations with a relatively small range of negative selection coefficients cause weak background selection in D. melanogaster, while the majority of deleterious amino-acid mutations are selected against effectively.
However, the mechanism may not be straight-forward, with some deleterious mutations being selected against (purifying selection), and some possibly undergoing positive section [24].
Consequently, this marker was excluded for further analysis, and the KRAS, BRAF and PIK3CA mutations were selected for combined mutational analysis.
Earl and Deem found that larger mutational shifts (recombination/swapping rather than point mutations) were selected for, and became dominant, when landscape shifts occurred faster and/or were larger.
Plasmids with correct insertion and without mutations were selected.
As a control group 59 tumors with p53 missense mutations were selected by matching with the p53 null tumors on the basis of patient age at diagnosis, stage and grade of cancer, cancer site, and year of diagnosis.
