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These subsequent mutations are restricted to subpopulations of cells where they contribute to clonal fitness and thus influence resistance to treatment and patient survival.
Three of these four did not have mutations in their blood cells, suggesting that the mutations are restricted to heart tissue, the group reports in the 22 June New England Journal of Medicine.
Finally, the phenotypic effects of most mutations are restricted to specific pathways and/or processes.
TP53 mutations are restricted to the SHH and WNT subgroups.
The severe α-thalassaemia mutations are restricted to Southeast Asia and some of the Mediterranean islands.
AID on-target mutations are restricted to genomic IgV and Sμ DNA regions.
Similar(49)
Mixtures and reeds seem to have been unknown, and mutations were restricted to a single 12th.
Cell sorting and amplicon sequencing from a follow-up sample confirmed that the discovered mutations were restricted to the CD8+Vβ1+ population (Fig. 3g).
Mutagenesis in mucA was restored by the addition of a new SSR C6-SSR4311), and even synergistically increased when G5-SSR426 C6-SSR431R431 were present simultaneously, with the mucA mutations being restricted to −1 bp deletions within any of both G C SSRs.
We identified H3.3-K27M H3.3-K27M in mutationsumours whereas H3-G34R/V mutatinns were restricted to the cerebral hemidlinees.
Mutations were restricted to codon Q209 and affected GNA11 more often than GNAQ (six and four samples, respectively).
More suggestions(15)
mutations are confined
developments are restricted
mutants are restricted
mutations are summarized
mutations are known
mutations are seen
mutations are observed
mutations are highlighted
mutations are sequenced
mutations are underlined
mutations are mapped
mutations are introduced
mutations are kept
mutations are summarised
mutations are replicated
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