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The IDH1 mutations are remarkably specific to a single codon in the conserved and functionally important arginine 132 residue (R132).
4, 5 The IDH1 and IDH2 mutations are remarkably specific to single codons: the conserved and functionally important Arg132 residue in IDH1 and the Arg172 residue in IDH2.
The IDH mutations are remarkably specific to arginine 132 (R132) in IDH1 and arginine 172 (R172) or arginine 140 (R140) in IDH2; IDH1/2 mutations are known to convert α-ketoglutarate to oncometabolite R-2-hydroxyglutarate.
11, 13 The heterozygous IDH mutations are remarkably specific to a single codon in the conserved and functionally important arginine 132 residue (R132) of IDH1 and 172 residue (R172) of IDH2.
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In both cases, the amount of cadmium needed to inhibit repair and increase mutations was remarkably small.
The phenotype associated with GCK mutations is remarkably similar for all mutations.
Like other researchers working in a variety of organisms, we find that TALENs are easy to design for new targets, the designs are quite often successful, and the frequency of induced mutation is remarkably high (Christian et al. 2010; Clark et al. 2011; Huang et al. 2011; Miller et al. 2011; Wood et al. 2011).
The two parameters characterizing the distribution of arising mutations are also remarkably close to the real values.
DOI: http://dx.doi.org/10.7554/eLife.01064.023 Despite the identification of the CMT2B mutations as hypomorphic alleles, our findings are remarkably consistent with the majority of previous biochemical findings.
Even though most mutations in tRNAs affect mitochondrial translation, the resulting clinical phenotypes are remarkably heterogeneous.
In line with classic mutation rate estimates from reporter gene assays, the emerging consensus is that the genomic mutation rate is remarkably constant across DNA-based microbes, ∼3 × 10−3 mutations/genome/generation (Drake 1991; Lynch 2010).
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