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If particular adaptive pathways are accessible only by specific types of mutations, mutators may be able to access them more readily because those types of mutations are relatively more common.
Although the majority of these mutations are relatively infrequent at diagnosis (at least at the population-level) they tend to accumulate as the disease progresses or at relapse.
Although these mutations are relatively rare, their discovery, reported in the January issue of Nature Genetics, could help point the way to other genes behind inherited epilepsies, which are thought to account for about 40% of all forms of the disease.
Somatic mutations are relatively common in plants, but usually only affect a portion of the meristem.
Because somatic mutations are relatively rare events, our analysis focuses on microsatellites (MS; repetitive DNA sequences with relatively high mutation rates) in mismatch repair (MMR -deficient organisMMR -deficient
Because TS mutations are relatively rare, they have been used most extensively in model organisms that are amenable to screens that enable one to search through large populations of mutagenized individuals for relatively rare conditional mutants.
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Mutations were relatively common in cancers of the lung, stomach, ovary, colon and kidney, and rare in cancers of the testis and breast, and in carcinoid tumors, which are usually found in the gastrointestinal tract.
Thus, the presence of activating GNAS mutations is relatively organ-specific.
In Icelandic BC women, it seems that the rate of BRCA1 mutations is relatively low.
PIK3CA mutations were relatively infrequent (10 of 102, 9.8%) in TNBC cases overall in TCGA dataset.
Although tumours harbouring both mutations were relatively rare, mutations in APC and K-ras seemed to occur co-dependently.
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