Sentence examples for mutations are prognostic from inspiring English sources

PI3- kinase mutations are prognostic for survival in independent datasets.

Some investigators claim that EGFR mutations are prognostic rather than predictive, because subset analysis of TRIBUTE or INTACT trials (comparing platinum chemotherapy with chemotherapy plus EGFR-TKI) indicated that patients with lung cancer having EGFR mutations did better even in patients treated only with chemotherapy (Bell et al, 2005; Eberhard et al, 2005).

13– 19 Several older studies suggest that KRAS mutation is prognostic in CRC patients.

The BRAF mutation was prognostic for overall survival in MSS and/or left-sided tumors subpopulations.

In the global population, the BRAF mutation is prognostic for poorer overall survival and survival after relapse, while KRAS mutation is not prognostic for any of the three endpoints (Table  1).

The test for interaction between BRAF mutation status and tumor site was not significant, hence we conclude that BRAF mutation is prognostic for SAR in all MSS patients.

BRAF mutation is prognostic for poorer OS (median OS mutation vs. wild-type, 8.6 vs. 20.8 months; P = 0.001; Fig. 3C).

High EGFR protein expression and exon 9 PIK3Cactivatingng mutations are independent prognostic factors in TNBC.

In conclusion, our data show that BRAF and NRAS mutations are not prognostic in advanced melanoma.

It would follow that the BRCA1 and BRCA2 mutations are therefore prognostic markers for aggressive PRCA.

PIK3CA mutations are positive prognostic factors in breast cancer [ 21, 22], supporting the clinical utility of MPS for the detection of clinically actionable mutations.