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All other p53 mutations are (probable pathogenic) amino acid substitutions and all except one have been published previously [ 29](Table 4).
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In the absence of somatic driver mutations, it is probable that such selection is driven by well-demonstrated epigenetic differences between individual HSCs (Fraga et al., 2005) or by stochastic events.
But many changes are probable.
Conflicts are probable.
In fact, they are probable".
Other risk factors are probable.
The output of ANGDelMut suggests the nature of the mutation; it's probable association with ALS, and further highlights the plausible molecular mechanisms of loss-of-functions to the user.
Beneficial or compensatory mutations are systematically less probable than deleterious ones, the ratio between both types being strongly dependent on the degree of optimization of the population.
The probable mutations are ranked starting from the most likely to be pathogenic according to the following list: nonsense, frameshift, essential splice site (affecting the conserved consensus intronic positions), start loss, stop loss, missense, predicted splice site mutation (outside of the consensus sites), in frame indels, and synonymous coding.
Of these, 67 were determined to carry the familial BRCA2 mutation and 116 men were probable mutation carriers.
However, given the large number of epitopes resulting from the MHC polymorphism and the probable cost of mutations, viruses are probably limited in their attempts to reduce epitopes.
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CEO of Professional Science Editing for Scientists @ prosciediting.com