Sentence examples for mutations are presumed from inspiring English sources

Conversely, most protein truncating BRCA1/2 mutations are presumed to be pathogenic, thereby permitting women harboring such mutations to be provided appropriate clinical counseling and management.

Protein-truncating nonsense mutations and frameshift mutations are presumed to have a different impact on the functional impairment of the ATP7B protein than missense mutations and are hypothetically more 'severe' mutations than these.

Clinical phenotypes are evident for altered SLC1A3 function, including ataxia or epilepsy, but this may be a consequence strictly resulting from protein-coding mutations, as known disease-linked mutations are presumed to act in a dominant negative fashion in the assembled homotrimeric transporter [ 35].

The coexistence of BRAF and KRAS mutations is presumed to be incompatible with proliferation, hence a negative selection for concurrent existence of both mutations [12].

Yet another recent study of adaptation in large yeast populations did not observe that the speed of adaptation decreased during adaption under conditions where multiple mutations were presumed to be pervasive, and found that variation in fitness was higher at higher Nμb, supporting the multiple mutation model of adaptation [ 9].

In the remaining 24 patients, the mutation was presumed to be recessively acting.

The mutation was presumed to render the enzyme inactive on two accounts.

Mutations in NDUFS7 are presumed to affect either the catalytic activity or proper assembly of complex-1.

These conserved metabolite correlations regardless of the mutations in mto1 and tt4 are presumed to reflect the fundamental metabolic regulations underlying plant metabolic systems.

Mutations in the KRAS oncogene are presumed responsible for PDAC initiation and seen in the earliest PanIN lesions in nearly all cases.

A Genetic Component Five to 10 percent of pancreatic cancer patients have a family history of the disease and are presumed to carry mutations that impair their body's ability to repair damage to DNA.