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Indeed, the three primary mutations are prerequisites for LHON, and many other rare LHON mutations are discovered continuously (c.f. http://www.mitomap.org/MITOMAP/MutationsLHON).
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Are we allowed to think that progressive evolution causally related to the harmful mutations even if they are prerequisites for their overcoming by subsequent evolution?
"These are prerequisites".
Hollywood movie stars are prerequisites.
Both are prerequisites of the decent existence".
They are prerequisites for great student learning.
Both are prerequisites for notification.
Deleterious mutations are much easier to study than beneficial mutations.
Information about the spectrum of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) mutations is a crucial prerequisite for screening programs.
Generation of mutations is an essential prerequisite for culture adaptation.
This implies that the generation of phase 1 mutations is not a prerequisite for the expression of phase 2 mutations.
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