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Lists of more than 600 different HPRT mutations are posted in the research sections at http://www.lesch-nyhan.org/.org/
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Henry L. Niman, who runs a Web site tracking flu mutations, complained that many swine sequences are posted by American universities and in Mexico only on private databases.
Rare post-zygotic mutations are likely to have been underestimated in the past.
In the literature, post-zygotic mutations are defined as mutations that arise in development during organogenesis, at the zygote stage.
Post-zygotic mutations are somatic mutations occurring during the early development of the zygote, resulting in a mosaic distribution of normal and mutant cells in tissues or organs of affected individuals (Weinstein 2006).
Retrospective studies have identified that patients homozygous for JAK2V617F mutations are more likely to progress to post-PV MF.
Deleterious mutations are much easier to study than beneficial mutations.
All mutations are accidental changes to DNA.
Mutations are not supposed to revert spontaneously".
As many of the post-treatment plasma samples in this study were collected long before clinical recurrence, we cannot conclude that these mutations are associated with therapeutic resistance.
Mutations are never beneficial.
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