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For computational efficiency, a maximum of four mutations are permitted to occur in a single cell per division.
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Notice that each mutation is permitted to teleport to any patient and each patient is permitted to teleport to any mutation with a small probability.
Markers and QTL were both di-allelic, and recurrent mutation was permitted during the historical generations at a rate of 2.5 × 10-5.
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Moreover, there may be certain situations where certain potent BRAF mutations (Val→Glu) and RAS mutations are not permitted in the same cell, as they might result in hyperactivation of Ras/Raf/MEK/ERK signaling and expression, which could lead to cell cycle arrest [ 75].
That this was permitted by a mutation which constantly generates brains that push the upper limits of the possible is a speculation.
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