K-ras mutations are one of the commonly believed mechanisms of CRC development.
First, mutations are one possible cause of a disruption in morphostats (but there are other possible causes as well).
KRAS mutations are one of the earliest genetic abnormalities in the progression model for pancreatic cancer [ 26].
MAPK signalling pathway is a downstream target of Ras family members and activating KRAS mutations are one of the main features underlying CC development and resistance to therapy.
In the Fearon and Vogelstein model, activating KRAS mutations are one of the first genomic events leading to the development of CRC.
Although spontaneous mutations are one of the main driving forces behind evolution and enable organisms to adapt to specific ecological niches, most mutations are neutral or even deleterious (Drake, 1991).
1, 4 ETV6 mutations are one of the predictors of poor overall survival in MDS. 1 Other mutations of transcriptional factors, including CEBPA, NPM1, and GATA2, have been described not only in AML but also in <5% of MDS.
Analysis of genetic mutations is one of the most effective techniques for investigating gene function.
Among these mutations, HBB −28 (A>G) mutations is one of the three most common mutations in China and Southeast Asia patients with β-thalassemia.
The development of HIV resistance mutations is one of the major problems for optimizing treatment of HIV-infected patients.
