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Interestingly, at least 500 mutational catalogs with an average of 96 mutations per catalog (a total of ∼50,000 mutations) are needed to decipher five mutational processes, but these five mutational processes can be more easily deciphered from 50 cancer genomes containing an average of 480 mutations (a total of ∼25,000 mutations, Figure 3D).
Taken together present finding clearly indicate that alterations in DDR genes are relevant for development of canine cancer, however to shed more light on tumor-associated defects, further investigations of different canine tumor types with regard to their mutational status and in particular the functional effects of mutations are needed.
This implies that two independent mutations are needed to change glycine to serine in An. funestus.
Therefore, further investigations into cellular mechanisms of cochlear pathogenesis resulted from Cx mutations are needed.
While highlighting the qualitative aspects of our study, parameter estimates from in vivo data associated with resistant mutations are needed to provide more accurate quantitative predictions.
Further experiments comparing topo IIα activity in colon cancer cell lines harboring various truncating APC mutations are needed to establish a direct link between topo IIα activity and aneuploidy.
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Other research has indicated that genetic vulnerability to autism differs between males and females, with more mutations being needed to produce the condition in females compared with males.
A comprehensive approach to the study of TAAs resulting from genetic mutations is needed to translate this information into advances in treatment.
A rapid genotyping test with high accuracy, selectivity, and reproducibility suitable for the determination of known mutations is needed for prenatal screening and post-natal diagnosis of this disease in clinical setting.
More analysis, including protease inhibitors resistance mutations, is needed to fully understand the underlying mechanisms of reversion of multi-drug resistant HIV in the absence of drug pressure.
A full reconstruction of this complex landscape of adaptive mutations is needed for elucidation of biological mechanisms of viral adaptations to humans.
More suggestions(15)
mutations are identified
mutations are associated
transfer are needed
mutations are greater
mutations are suitable
mutations are instrumental
mutations are summarized
mutations are seen
mutations are observed
mutations are sequenced
mutations are underlined
mutations are mapped
mutations are kept
mutations are replicated
mutations are termed
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