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Nonsense and frameshift mutations are most common and are associated with severe disease.
Some scientists have criticized TCGA for focusing on gene sequencing while diverting funds from functional studies that can determine which of the hundreds of mutations are most important.
Further sequencing efforts revealed that mutations are most prevalent in WHO grade II/III gliomas (71%) and secondary GBMs (88%) but less common in primary GBMs (7%) (Balss et al., 2008).
For example, evolutionary biologists disagree about what sort of mutations are most likely to contribute to adaptive evolutionary change (Hoekstra and Coyne 2007), whether Homo habilis is the direct ancestor of modern humans or an ancient cousin (Fig. 3; Spoor et al. 2007), and how important hybridization is in the process of speciation (Mallet 2007)—to name just a few.
The GC content [2] or the higher susceptibility of some codons to mutations are most likely influencing the codon bias strength in different organisms.
Our knowledge of the activities of MeCP2 suggests that the pathologies associated with MECP2 mutations are most likely due to the misregulation of neuronal genes.
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KRAS mutations were most frequent and identified in 132 (42%) tumors, followed by APC in 79 (25%) and TP53 in 64 (21%) tumors.
The perceivable differences between the control and experimental groups, inclusion of content addressing timelines, sizes of beaks, and mutations, is most likely attributed to the divergent interaction with the situations of chance tutorial by the groups.
Low-abundance PI mutations were most commonly seen, occurring in 18 of 22 subjects (82%); however the majority was "minor" IAS-USA PI mutations [23].
The percentage of sequences having a drug resistance mutation is shown in Figure 2. NRTI resistance associated mutations were most frequently found with a prevalence of 62% [13].
KATP channel mutations were most common, accounting for 15% of cases.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com