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These mutations are interpreted as optional for the respective clade of the mitochondrial phylogeny by EMMA.
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Typically, a strong correlation between amino acid mutations is interpreted as evidence of functional interactions under substantial selection pressure.
Both independent mutations were interpreted as independent NF2 second hits.
Antiretroviral resistance mutations were interpreted with the HIVdb programme of the Stanford University HIV Drug Resistance Database.
Activating mutations in this gene are interpreted as a poor prognostic factor in CRC patients [ 13].
The first group contained those mutations restricted to the 6½ exons within Dp140utr which are interpreted principally as mutations of Dp427 and Dp260 (N = 14, listed as ABB* in Table 1).
The results of these experiments are interpreted through the mutation induced changes in the predicted 3'SS regulatory elements [see Additional File 1 Table S3].
The limit of this latter approach, however, is that a much lower number of mutations can be interpreted as potential CTL escape mutation.
This underscores that missense mutations must be interpreted with care.
The high accumulation rate of mutations can be interpreted partially as genes being under less selective constraint.
Thus, the phenotypes of any resistance mutations should be interpreted with caution because some of them could have indirect (allosteric) effects.
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