Sentence examples for mutations are in from inspiring English sources

Almost all known harmful mutations are in exons and cause disease by directing a misformed protein.

The target sequence is in blue, and mutations are in red.

Novel technologies for detection of lower abundance mutations are in development51,52,53, although their throughput and coverage is limited.

Most of these mutations are in two genes, one of which codes for myosin, a protein crucial to muscle contraction.

The NA mutations are in previously conserved catalytic and structural residues, Glu 119, Arg 152, Arg 292, and His 274.

The functional consequences of these hot spots were tested by several groups through the overexpression of these hot spots or gene deletion experiments using somatic cell knockouts and have demonstrated that these mutations are in fact oncogenic.

Most of the mutations are in proteins that modify histones, which are the proteins that the DNA is wrapped around, often represented as packages of round beads bound together by strands of DNA.

The most common EGFR mutations are in-frame deletions in exon 19 and L858R point mutations in exon 21.

About 90% of the sensitising mutations are in-frame deletions in exon 19, affecting the conserved amino acids LREA, and the point mutation L858R in exon 21.

In contrast, C-terminal CEBPA mutations are in-frame insertions or deletions, thereby affecting DNA binding and homo- or heterodimerisation with other CEBP family members (Nerlov, 2004).

The most common EGFR activating mutations are in-frame deletions in exon 19 or point mutations in codon 858 in exon 21 [ 10].